The integration of sensor networks within aircraft structures for large-area load localization enables accurate assessment of structural health and appropriate maintenance, which is of great significance for the safe upkeep of aircraft. The technology of structural electronics integration offers new concepts for the integration of sensor networks with structures. Inspired by this, this chapter presents the realization approach of integrating the sensor network and structure based on screen printing. The method has the advantages of large-area fabrication, batch fabrication, simple equipment, low cost, and good substrate and ink adaptability, which is conducive to the preparation of flexible sensor networks and their integration with structures. Based on this approach, the integrated design and preparation of the large-area load localization sensor network and structure were accomplished, and the load localization function was verified with a localization accuracy of 90%. The results demonstrate that this method holds significant application value in achieving the structural integration of load positioning in aircraft.