This study was aimed to compare the effect of proprioceptive neuromuscular facilitation and functional stabilization exercise in reducing symptoms associated with patellofemoral pain syndrome. A total of 60 subjects were selected and divided into two groups that includes proprioceptive neuromuscular facilitation group (n = 30) and functional stabilization exercise group (n = 30). The kujala score and an angulus smartphone goniometer were used to evaluate the functional activity and range of motion. Both interventions were given for four weeks, four sessions per week for 40 min. The paired and unpaired tests were used to analyze the values. The pretest and post-test values were analyzed by using the kujala score and an angulus smartphone goniometer application in both groups. The mean value of the proprioceptive neuromuscular facilitation group was found to be more significant than the functional stabilization exercise with a p value of <0.0001. The study revealed that proprioceptive neuromuscular facilitation was found to be more successful in functional activity and range of motion than the functional stabilization exercise among the subjects with patellofemoral pain syndrome.