Cervical spondylosis, a degenerative condition which affects the vertebrae and intervertebral discs of the neck. Forward head posture causes misalignment of vertebrae and tightness in suboccipital muscles. This leads to wear and tear degeneration of vertebrae, resulting in cervical spondylosis and reduced mobility. 66 participants with age group of 30–55 yrs were selected based on inclusion criteria. Pre test and post test analysis were carried out with kinovea software to measure CV-angle, Upper cervical spine ROM. Pressure algometer, Neck disability index (NDI) scale is used. Participants were equally assigned into two groups: Dry needling therapy (DNT) group (n = 33) and Instrumental assisted soft tissue mobilization group (IASTM) (n = 33). Total duration for both groups were carried out for 4 weeks. Results were statistically analyzed by paired and unpaired t-tests. Results suggested that the DNT group has significant improvement than IASTM with p value < 0.0001. The study discovered that in patients with cervical spondylosis, dry needling therapy was superior to instrumental-assisted soft tissue mobilization.