Pathogenic microorganism-induced plant diseases provide a significant challenge to agriculture, causing 30–40% of crop loss. It has been determined that using chemical pesticides has a negative impact on both the environment and human health. Consequently, it has become imperative to investigate natural alternatives to address these issues. The largest taxonomic group in microbial world that produces antibiotics is Streptomyces, a Gram-positive bacterium, which has been the subject of much investigation because of its propensity to produce a variety of antimicrobial substances, including organic compounds and metabolites. Researchers from worldwide investigated a number of techniques and strategies to extract novel bioactive chemicals from these microorganisms. Streptomyces can be used as biocontrol agents that contribute to the crop productivity and lower the use of agrochemicals against plant pathogens, promote plant growth, and reduce abiotic stresses that shed more light on profitable and environment-friendly method in promoting sustainable agriculture. The biofertilizers from Streptomyces effectively control plant pathogens through nitrogen fixation, solubilization of phosphate, and production of plant growth regulators, which lead to improve the overall soil health. The Streptomyces produces major secondary metabolites that impact other microbes and plants, which play an important role in biological control. These prospects are reinforced by promising results in controlling phytopathogens, promoting sustainable agriculture, and integrating pest management strategies for agricultural use. The present chapter highlights key commercial biofertilizers and biocontrol agents derived from Streptomyces, ensuring enhanced efficacy, broader applicability, their mechanism of action such as inducing systematic resistance, and antibiotic and enzymatic degradation of pathogens. Additionally, it can explore how these bioproducts support organic farming, sustainable agriculture, and climate-resilient crop production.