This chapter introduces the RaiiSE™ framework, a structured, evidence-based approach that transforms startup fundraising from a chaotic, reactive process into a strategic discipline. Built on Design Science Research methodology, RaiiSE addresses the critical reality that only 14–25% of seed-funded startups successfully raise Series A rounds, primarily due to three common errors: misaligning capital with strategy, poor timing, and inefficient processes. The framework is anchored in three core design principles—Strategic Clarity (WHY you’re raising), Investment Readiness (WHEN to approach investors), and Process Savviness (HOW to execute effectively)—that work together to increase founders’ odds of securing the right capital on favorable terms. To translate these principles into action, the chapter provides three practical tools: the RaiiSE Process (a three-stage iterative roadmap through Reflecting, Enacting, and Closing), the RaiiSE Capital Raising Canvas (a single-page visual planning tool that documents key elements across all stages), and seven evidence-based guidelines for navigating critical fundraising decisions. By implementing this integrated system, founders can replace anxiety-inducing scrambles with strategic campaigns that have clear objectives, defined milestones, and systematic execution, ultimately transforming fundraising from mysterious art into repeatable science.