Epoxidizing of palm kernel oil (PKO) encourages responsible production by utilizing renewable feedstocks, minimizing environmental harm, and potentially replacing non-renewable, petroleum-derived epoxides, thus supporting SDG 12 that relates to responsible consumption and production. PKO, derived from the seed kernel of oil palm fruit, possesses a high content of saturated fatty acids with limited unsaturation, which restricts its direct application in high-value chemical transformations. However, chemical modification through epoxidation offers a promising pathway to enhance its functional properties and expand its industrial application. This brief review provides an overview of the epoxidation process as applied to PKO, including the reaction mechanisms, common epoxidizing agents, and catalytic systems used. Comparisons are made with other vegetable oils such as soybean and canola oil, highlighting the challenges and opportunities unique to PKO due to its distinct fatty acid profile. The review also discusses the potential applications of epoxidized PKO in producing biopolymers, lubricants, and other bio-based materials. Additionally, key challenges such as low double-bond availability, process efficiency, and environmental concerns are addressed, along with suggestions for future research directions to optimize the epoxidation process of PKO-based epoxides.