The United States (U.S.) has often shown itself as a nation to be forward-thinking in terms of advancing space activities, and this includes the pursuit of space resources. It has been competitive in staying ahead of other nations and maintaining a leading role in outer space. This chapter sets out to review and explore the impact, direction, and influence of the U.S. in the domain of space activities, which precede a United Nations and international approach. This is undertaken through the discipline of law, policy, strategy, and, arguably, includes space politics or astro-politics. It finds that the U.S.’s approach, centred around space resource, has largely been driven by a lack of international agreement in terms of permissible actions tolerated, or prohibited, in outer space. Yet, the U.S. approach is not without criticism in terms of the legalities of extending domestic legislation into the space domain and, invariably, into a global common for humanity. That said, perhaps in a bid to counter some of these arguments, the U.S.’s more recent direction has been to bring in other players, or nations, that agree to its wider space strategy and policy movements – in the form of the Artemis Program. Hence the Artemis Accords is further discussed, before attention is turned to other nations’ domestic legislation which adopts a similar stance to the U.S. Invariably, it is concluded that challenges are likely to occur to these approaches when space resource extraction or mining in space actually becomes a reality and occurs.