Recent advancements in materials science and device fabrication have led to the development of a new generation of biosensing devices that are portable and capable of non-invasive or minimally invasive detection. These devices enable long-term monitoring of various physiological parameters and biomarkers associated with multiple diseases. Wearable technology allows doctors, sports teams, and endurance athletes to track physiological markers, workloads, and functional movements, optimizing performance and reducing the risk of injury. As a result, both the general and sports teams can increasingly benefit from wearable performance gadgets and sensors. This chapter discusses the applications of nanotheranostics in medicine, regenerative medicine, personalized medicine, sensor fabrication, and fabric construction, as well as the challenges and future directions in sports wearable technology. By integrating wearable healthcare devices with the latest innovations in point-of-care diagnostics, these developments will revolutionize health monitoring and management, creating a more empowered and connected experience for everyone.