Proton pump inhibitors (PPIs) are currently the main drugs for treating gastroesophageal reflux disease (GERD). Due to the limitation of its therapeutic effect, 17%–32% of patients still have reflux symptoms after taking PPIs, some patients need long-term or even life-long medication, and about 75%–90% of patients show reflux symptoms after withdrawing [1]. Although laparoscopic fundoplication can relieve recurrent reflux symptoms, less than 5% of patients have received laparoscopic fundoplication due to the massive surgical trauma and higher surgical indications compared with endoscopy [2]. As a result, about 25%–30% of GERD patients have poor curative effects after taking drugs or cannot tolerate long-term medication but are unwilling to carry out surgical treatment. The emergence of gastroesophageal reflux endoscopic treatment technology is filling this gap [3–5].

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Endoscopic Fundoplication for Gastroesophageal Reflux Disease

  • Feng Du

摘要

Proton pump inhibitors (PPIs) are currently the main drugs for treating gastroesophageal reflux disease (GERD). Due to the limitation of its therapeutic effect, 17%–32% of patients still have reflux symptoms after taking PPIs, some patients need long-term or even life-long medication, and about 75%–90% of patients show reflux symptoms after withdrawing [1]. Although laparoscopic fundoplication can relieve recurrent reflux symptoms, less than 5% of patients have received laparoscopic fundoplication due to the massive surgical trauma and higher surgical indications compared with endoscopy [2]. As a result, about 25%–30% of GERD patients have poor curative effects after taking drugs or cannot tolerate long-term medication but are unwilling to carry out surgical treatment. The emergence of gastroesophageal reflux endoscopic treatment technology is filling this gap [3–5].