Currently, various types of fillers are used for facial plastic surgery and penis enlargement under the name of being approved by the Food and Drug Administration. However, various side effects occur because the characteristics of tissue enlargement are different depending on the type and characteristics of the filler and the enlarged body part. Therefore, in this chapter, we intend to help both filler operators and patients for penis enlargement by examining the development and development process of fillers and the characteristics of each filler and the advantages and disadvantages of the results of penis enlargement.