This chapter explores the theoretical basis and clinical evidence supporting the use of glans penis augmentation (GPA) with hyaluronic acid (HA) filler as a novel therapeutic approach for premature ejaculation (PE). It presents results from human clinical studies evaluating GPA alone, dorsal neurectomy alone, and a combined approach, including the author’s published 5-year follow-up outcomes. These findings provide insights into the potential efficacy, safety, and long-term durability of GPA in managing PE, particularly in patients with glans hypersensitivity.