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Premature ejaculation (PE) is a multifactorial male sexual dysfunction characterized by reduced intravaginal ejaculation latency time (IELT), inability to control ejaculation, and negative psychosocial consequences. The etiology involves complex interactions among neurobiological, hormonal, sensory, and autonomic systems. Current treatment modalities, including pharmacotherapy, behavioral therapies, and surgical interventions, target different pathophysiological mechanisms but often fail to provide lasting solutions due to side effects, poor adherence, or incomplete efficacy. Among emerging interventions, glans penis augmentation (GPA) with hyaluronic acid (HA) filler offers a novel, minimally invasive approach by attenuating peripheral sensory hypersensitivity—a key contributor in lifelong PE. This chapter synthesizes contemporary insights into PE pathophysiology, reviews existing treatment strategies, and positions GPA with HA filler as a mechanism-specific, reversible therapeutic option supported by clinical evidence.

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Premature Ejaculation: Integrating Pathophysiology with Current Treatment Modalities

  • 章节

  • 发表日期：

    2026年

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  • Du Geon Moon

摘要

Premature ejaculation (PE) is a multifactorial male sexual dysfunction characterized by reduced intravaginal ejaculation latency time (IELT), inability to control ejaculation, and negative psychosocial consequences. The etiology involves complex interactions among neurobiological, hormonal, sensory, and autonomic systems. Current treatment modalities, including pharmacotherapy, behavioral therapies, and surgical interventions, target different pathophysiological mechanisms but often fail to provide lasting solutions due to side effects, poor adherence, or incomplete efficacy. Among emerging interventions, glans penis augmentation (GPA) with hyaluronic acid (HA) filler offers a novel, minimally invasive approach by attenuating peripheral sensory hypersensitivity—a key contributor in lifelong PE. This chapter synthesizes contemporary insights into PE pathophysiology, reviews existing treatment strategies, and positions GPA with HA filler as a mechanism-specific, reversible therapeutic option supported by clinical evidence.