Bioprocess technology involves the production of industrially important products using economical raw materials, including value-added products from various sectors such as pharmaceuticals and healthcare, food and beverages, biofuels and specialty chemicals, and environmental management and agriculture. Bioprocessing technology offers advantages over chemical processing in terms of sustainability, specificity, scalability, and the ability to operate under mild conditions. The major aspects of bioprocessing technology are the design and development of equipment, materials, and processes. With the introduction of metabolic engineering for strain improvement, hyperproducers have been developed, which have become the first choice for industrial bioprocesses. In recent years, the thrust of the bioprocess industry has shifted toward net-zero targets to reduce energy consumption and minimize carbon footprint. Researchers have developed processes for continuous reactors that feature in situ product recovery. This chapter focuses on the technologies practiced in the industry, covering research and development in metabolic engineering and bioreactor design for upstream and downstream bioprocess intensification.