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Glycans play crucial roles in regulating the behavior of cell surface and membrane-associated proteins. Recent developments in synthetic glycan modification techniques have enabled precise manipulation of glycan structures on specific proteins, providing new insights into the roles of glycans in controlling protein dynamics. This chapter summarizes recent progress in this field, focusing on two major areas: (1) the regulation of membrane protein dynamics using HaloTag-mediated glycan display systems, and (2) the enhancement of antibody therapeutic functions via glycan–lectin interactions. By integrating chemical biology, molecular imaging, and glycobiology, researchers have begun to dissect the structure–function relationships of glycans with unprecedented resolution. Particular attention is paid to the functional roles of galectin-3-mediated lattice formation, membrane diffusion. These technologies not only improve our understanding of glycan biology but also open new avenues for therapeutic engineering.

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Regulation of the Dynamics of Antibodies and Cell Membrane Molecules Through Synthetic Glycan Modification

  • 章节

  • 发表日期：

    2026年

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  • Kazuya Kabayama,
  • Yoshiyuki Manabe

摘要

Glycans play crucial roles in regulating the behavior of cell surface and membrane-associated proteins. Recent developments in synthetic glycan modification techniques have enabled precise manipulation of glycan structures on specific proteins, providing new insights into the roles of glycans in controlling protein dynamics. This chapter summarizes recent progress in this field, focusing on two major areas: (1) the regulation of membrane protein dynamics using HaloTag-mediated glycan display systems, and (2) the enhancement of antibody therapeutic functions via glycan–lectin interactions. By integrating chemical biology, molecular imaging, and glycobiology, researchers have begun to dissect the structure–function relationships of glycans with unprecedented resolution. Particular attention is paid to the functional roles of galectin-3-mediated lattice formation, membrane diffusion. These technologies not only improve our understanding of glycan biology but also open new avenues for therapeutic engineering.