Macao is a Special Administrative Region of China, and its higher education is an integral part of China's higher education system. Since the 1980s, Macao has successively established 10 higher education institutions (HEIs), forming an open higher education system with both public and private institutions of different types. After returning to the motherland in 1999, Macao's higher education has developed rapidly, and the overall level of teaching, scientific research and internationalization has been further improved. However, due to historical and practical reasons, Macao's social and industrial structure is relatively monotonous, which has affected the discipline layout and talent cultivation in Macao's higher education institutions. In addition, there has been a lack of a long-term coherent education policy. The advantage of higher education in serving the national development is not obvious, and the willingness and initiative of young students in participating in the construction of the Guangdong Hong Kong Macao Greater Bay Area (GBA) is not strong. The reform of higher education in Macao is a steady and orderly process, which requires the cooperation and joint participation of government, HEIs, teachers, and students. Through institutional construction, discipline construction, promoting university-industry-research cooperation, and strengthening international and domestic cooperation, the enthusiasm and initiative of Macao's young students to be engaged in the GBA construction can be enhanced, so as to support the high-quality development of local economy, society and higher education. Macao's HEIs should actively integrate into the GBA construction, and build a deep cooperation mechanism with HEIs, research institutes and enterprises in Chinese mainland, so that Macao's higher education can realize its own long-term and sustainable development while assisting the national construction, and further promote the steady and enduring growth of the cause of “one country, two systems”.