Gastric cancer is ranked among the top five most common cancers in the world, and it contributes to significant cancer-related mortality burden. Global trends indicate a higher prevalence of gastric cancer in specific geographic regions like Japan, Southeast Asia and China. Aetiology of gastric cancer is multifactorial, mostly related to infections and dietary habits. Epidemiological trends also indicate a migration from distal gastric to proximal gastric cancer globally. The majority present with locally advanced stage and early gastric cancers are mostly seen in countries like Japan with a screening program. Traditionally, radical surgery is the mainstay of therapy, along with adjuvant systemic chemotherapy. Radiotherapy has very limited role and indication in gastric cancer management. Recently, advances in molecular and genetic fields are opening new therapeutic avenues in the management of gastric cancer.