The conventional reliance on a single reference genome falls short in capturing the full spectrum of genetic diversity within a population. Pangenomes overcome this limitation by integrating genetic variations from multiple individuals, offering a more comprehensive view of species-wide genomic diversity. A pangenome typically comprises the core genome, shared by all individuals, and the dispensable or accessory genome, which contains genes present in some but not all individuals. These variable regions often include genes related to adaptation, stress resistance, and other traits shaped by environmental and evolutionary pressures. By revealing both conserved and unique genomic elements, pangenomes provide critical insights into intra-species variation, structural rearrangements, and functional genomics. With the rapid advancements in sequencing technologies and the exponential growth of genomic data, plant pangenomics has progressed beyond single-species frameworks. This progression has given rise to super-pangenomes, which span all genomic sequences across an entire genus. These super-pangenomes are particularly valuable as they incorporate both domesticated and wild species, enabling deeper insights into evolutionary trajectories, domestication events, and haplotype patterns unique to wild lineages. Such insights are essential for understanding genetic diversity, tracing evolutionary dynamics, studying domestication, and formulating advanced breeding strategies. This chapter explores the development and significance of pangenomes and super-pangenomes, emphasizing their critical role in harnessing wild genomic variation for crop improvement.

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Pangenomes, Super-Pangenomes and Beyond

  • Aamir W. Khan,
  • Saurabh Gupta,
  • Henry T. Nguyen

摘要

The conventional reliance on a single reference genome falls short in capturing the full spectrum of genetic diversity within a population. Pangenomes overcome this limitation by integrating genetic variations from multiple individuals, offering a more comprehensive view of species-wide genomic diversity. A pangenome typically comprises the core genome, shared by all individuals, and the dispensable or accessory genome, which contains genes present in some but not all individuals. These variable regions often include genes related to adaptation, stress resistance, and other traits shaped by environmental and evolutionary pressures. By revealing both conserved and unique genomic elements, pangenomes provide critical insights into intra-species variation, structural rearrangements, and functional genomics. With the rapid advancements in sequencing technologies and the exponential growth of genomic data, plant pangenomics has progressed beyond single-species frameworks. This progression has given rise to super-pangenomes, which span all genomic sequences across an entire genus. These super-pangenomes are particularly valuable as they incorporate both domesticated and wild species, enabling deeper insights into evolutionary trajectories, domestication events, and haplotype patterns unique to wild lineages. Such insights are essential for understanding genetic diversity, tracing evolutionary dynamics, studying domestication, and formulating advanced breeding strategies. This chapter explores the development and significance of pangenomes and super-pangenomes, emphasizing their critical role in harnessing wild genomic variation for crop improvement.