Nanotechnology is one of the innovative approaches that utilizes engineered materials to assist the management of multitudes of ailments, including neurodegenerative disorders (NDDs). Diverse nanocarriers such as nanomicelles, nanoliposomes, lipid nanoparticles, polymeric nanoparticles, and carbon nanotubes offer various advantages, including improved retention impact and penetration, precise administering and targeting, enhanced bioavailability, stability, and reliability. In recent years, plant as a whole or their derived compounds/secondary metabolites are gaining the utmost attention of investigators for their utility in the therapeutic management of various NDDs like Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), etc. This chapter briefs the therapeutic efficacy of different natural product-based nanoformulations for NDDs management with special emphasis on their possible mode of action, merits, and limitations evident in preclinical and/or clinical studies.