Pancreatic secondary tumors refer to malignancies metastasizing to the pancreas from other primary sites. Common primary origins include renal cell carcinoma, lung cancer, colorectal carcinoma, breast cancer, gastric cancer, and melanoma. Clinically, patients may present with abdominal pain, jaundice due to biliary obstruction, weight loss, or nonspecific digestive symptoms; Some cases are misdiagnosed as primary pancreatic adenocarcinoma due to overlapping imaging features. Diagnosis relies on multimodal approaches: medical history, contrast-enhanced CT/MRI and pathology biopsy. Management is dictated by the primary tumor’s biology and extent. Surgical resection may be considered for isolated metastases.  This chapter provides some classic and rare case examples for reference.