Diabetic nephropathy (DN) is a concept based on histopathological diagnosis, confirmed when diabetes-specific glomerular lesions—such as nodular glomerulosclerosis or diffuse mesangial expansion—are observed. In contrast, diabetic kidney disease (DKD) is a clinical diagnosis applied as a comprehensive concept when (1) kidney damage is observed in the presence of diabetes and (2) diabetic pathophysiology is presumed to be involved in its progression. The classical course of DN is characterized by a progression from glomerular hyperfiltration to microalbuminuria, then overt proteinuria, and eventually a decline in eGFR. In contrast, DKD includes the following three non-classical subtypes in addition to this typical pattern.

错误:搜索内容不能为空,请输入英文关键词
错误:关键词超出字数限制,请精简
高级检索

Kidney Diseases

  • Masao Iwagami,
  • Kousuke Negishi

摘要

Diabetic nephropathy (DN) is a concept based on histopathological diagnosis, confirmed when diabetes-specific glomerular lesions—such as nodular glomerulosclerosis or diffuse mesangial expansion—are observed. In contrast, diabetic kidney disease (DKD) is a clinical diagnosis applied as a comprehensive concept when (1) kidney damage is observed in the presence of diabetes and (2) diabetic pathophysiology is presumed to be involved in its progression. The classical course of DN is characterized by a progression from glomerular hyperfiltration to microalbuminuria, then overt proteinuria, and eventually a decline in eGFR. In contrast, DKD includes the following three non-classical subtypes in addition to this typical pattern.