Hemorrhage bleeding may occur during apheresis due to (1) the underlying disease, (2) removal of slowly recovering coagulation factors, or (3) inadequate anticoagulant dosing. In (1), bleeding may improve with treatment. In (2), risk increases with repeated sessions, especially for factors with slow synthesis. In (3), proper dose adjustment is essential. Overall, the incidence of bleeding complications from plasma exchange is very low (0.02–0.2%) [1, 2].