When heavy metals (HMs) contaminate food, they pose a serious risk to both human health and the environment. This is due to their inability to decompose naturally and the presence of organic pollutants, which can persist in their harmful form for extended durations. HMs such as zinc (Zn), cobalt (Co), nickel (Ni), and iron (Fe) play notable roles in plant metabolic activities. However, if these metals exceed a plant’s needs, they can become toxic. Cadmium, lead, and zinc are superfluous minerals that the plant does not necessitate in any manner. The phytoremediation strategy was selected as the principal method because of its cost-effectiveness, minimal labor requirements, ability to maintain soil attributes, and potential to increase soil quality and fertility. Certain plants have the ability to absorb and store significant quantities of heavy minerals without displaying any signs of toxicity. These plants are commonly referred to as “hyperaccumulators.” Nevertheless, continuous exposure to these metals might injure certain plants, underscoring the crucial role of microorganisms in safeguarding these plants, increasing their effectiveness, and enhancing their ability to tolerate elevated concentrations of heavy metals. The objective of this chapter is to gather and record as much information as possible from current research on the serious problem of heavy metal contamination in the environment, along with the importance of using plant and biological approaches to address it, which has attracted the attention of experts.