This chapter presents our studies on the inhibitory effects of electrical stimulations on the epileptiform discharges generated by three methods: brief high-frequency stimulation and two epileptogenic agents (4-aminopyridine and picrotoxin). Results showed that both pulse and sinusoidal high-frequency stimulations (HFS) at the Schaffer collaterals (the hippocampal CA1 afferent fibers), can suppress epileptiform spikes induced by these methods. The stimulation patterns and action mechanisms can vary with the epileptogenic methods, involving processes such as desynchronization and depolarization block. The findings suggest customizing stimulation parameters (e.g., duration) and modes (e.g., open-loop and closed-loop) is essential for effectively suppressing various types of epileptiform discharges.