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This chapter presents our findings from different HFS paradigms using time-varying parameters, including gradient changes in pulse frequency and intensity, alternating pulses with dual parameters, inserting and deleting pulses in regular stimulation, and randomly varying inter-pulse-intervals within a small range. Under HFS-induced axonal block, stimulations with time-varying parameters can produce diverse neuronal responses. This creates opportunities for developing novel stimulation paradigms that can address a wide range of neuromodulation needs.

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Neuronal Responses to Axonal HFS with Time-Varying Parameters

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  • 出版模式：

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  • 发表日期：

    2026年

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  • Zhouyan Feng

摘要

This chapter presents our findings from different HFS paradigms using time-varying parameters, including gradient changes in pulse frequency and intensity, alternating pulses with dual parameters, inserting and deleting pulses in regular stimulation, and randomly varying inter-pulse-intervals within a small range. Under HFS-induced axonal block, stimulations with time-varying parameters can produce diverse neuronal responses. This creates opportunities for developing novel stimulation paradigms that can address a wide range of neuromodulation needs.