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Among neuronal structures, the axonal membrane has the shortest chronaxie, making it most susceptible to narrow pulses commonly used in neuromodulation techniques like deep brain stimulation (DBS). This chapter details our experiments in the rat hippocampal CA1 region, which verify intermittent axonal block caused by high-frequency stimulations (HFS). The experiments include both antidromic HFS (A-HFS) applied to the axons of recorded pyramidal neurons and orthodromic HFS (O-HFS) applied to presynaptic afferent fibers. The results showed that the axonal HFS can extend the refractory period of axons and alter the excitability of somata, causing a silent period without firing immediately after HFS cessation. The experiments also showed non-uniform clustered firing produced by HFS with constant pulse intervals.

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Neuronal Responses to Axonal High-Frequency Pulse Stimulations

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  • 出版模式：

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  • 发表日期：

    2026年

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  • Zhouyan Feng

摘要

Among neuronal structures, the axonal membrane has the shortest chronaxie, making it most susceptible to narrow pulses commonly used in neuromodulation techniques like deep brain stimulation (DBS). This chapter details our experiments in the rat hippocampal CA1 region, which verify intermittent axonal block caused by high-frequency stimulations (HFS). The experiments include both antidromic HFS (A-HFS) applied to the axons of recorded pyramidal neurons and orthodromic HFS (O-HFS) applied to presynaptic afferent fibers. The results showed that the axonal HFS can extend the refractory period of axons and alter the excitability of somata, causing a silent period without firing immediately after HFS cessation. The experiments also showed non-uniform clustered firing produced by HFS with constant pulse intervals.