The utilization of 3D printing technology for fabricating biodegradable materials has revolutionized medical applications, offering unprecedented flexibility and customization in healthcare. Biodegradable materials are gaining traction due to their ability to degrade harmlessly within the body, reducing the need for surgical interventions to remove implants. 3D printing enables the precise fabrication of complex geometries tailored to patient-specific needs, promoting personalized medicine. In orthopedics, for instance, biodegradable implants can mimic the mechanical properties of bone and gradually degrade as new tissue forms, supporting natural healing processes. In addition to implant customization, 3D printed biodegradable materials play a pivotal role in drug delivery systems. They facilitate the controlled release of therapeutic agents, ensuring precise dosing and minimizing systemic side effects. Such capabilities are crucial in personalized medicine, where patient-specific treatments can be developed based on individual physiological and pathological characteristics. Beyond implants and drug delivery, 3D printing of biodegradable materials holds promise in tissue engineering by creating scaffolds that support cellular growth and tissue regeneration. These scaffolds can be designed with intricate internal architectures to mimic natural tissues, facilitating integration and functionality. Challenges including material selection, degradation kinetics, and regulatory considerations remain, yet ongoing research and technological advancements continue to address these hurdles. As such, the convergence of 3D printing and biodegradable materials represents a transformative approach in advancing personalized medicine, improving patient outcomes, paving the way for more effective therapies, and shaping the future of healthcare.