Effective movement of goods throughout local and international supply chains depends much on Major Distribution Centers (MDCs). MDC operational performance has become a major factor influencing supply chain resilience and regional competitiveness as global distribution networks get more complicated and linked. Still, current studies provide scant direction on how to evaluate MDC performance using methodologies of structured, multi-dimensional analysis. This work closes this gap by using a hybrid approach to evaluate the operational performance of certain MDCs, combining a relational performance analysis tool with a preference-based weighting method. Applied to a collection of exemplary distribution hubs, the framework allows a balanced analysis of both quantitative and qualitative elements over several performance criteria. The report offers practical insights for managers and academics trying to maximize MDC efficiency and helps current initiatives to improve the distribution infrastructure. It also provides a basis for more research on performance evaluation models inside the field of distributions.