Earthquakes are among the most destructive natural disasters, often leading to significant losses, including damage to property and loss of life. Buildings are particularly vulnerable to earthquake forces, making their structural safety a critical concern. To assess this vulnerability, fragility curves are used to illustrate the probability of structural damage based on the intensity of ground motion, helping engineers and planners better understand and mitigate seismic risks. This study aims to develop the fragility curve for G + 19 RCC frame building of seismic zone III in India, designed according to Indian codes. Using the inter-story drift ratio calculated from time history functions analysis, the earthquake sets are taken from FEMA P695. In this study, a complete analysis of a high-rise asymmetric reinforced concrete structure has been analyzed using a spectrum-compatible approach that integrates response spectrum and time history data for the ground motions. Calculations for the Inter-Story Drift Ratio percentage and assessments of hinge state formation have been conducted for various earthquake scenarios. This strategy provides valuable insights for disaster response planning, damage assessment, loss estimation, and decisions regarding retrofitting. IDA curves have been generated to depict the relationship between the Inter-Story Drift Ratio (IDR) and Peak Ground Acceleration (PGA) at the point of collapse. Subsequently, a fragility curve has been constructed to represent collapse PGA, based on plotting the natural logarithm of X against the corresponding standard normal variable on a lognormal scale. To achieve this objective, a comprehensive fragility analysis has been performed, allowing for the determination of the probability of collapse under the specified design hazard.