Microwave-assisted drug delivery, which uses energy from microwaves to increase the precision and deliverability of a medicine at the designated spot, is one of the most recent developments in targeted therapeutic applications. Through controlled release, this technique can not only help the drug penetrate and absorb more readily, but it can also greatly boost its availability over an extended period of time. The microwaves interact with biological tissues through a variety of methods, including heat localization, cavitation, and induced hyperthermia, to deliver the medications. Attaching liposomes, nanoparticles, and hydrogel systems to microwaves can help them work better. The concept of microwave-assisted medication delivery systems and the numerous mechanisms governing them will be covered in this chapter. Additional elements that would be covered include this system’s applications, limitations, and complications.