This section explores the mechanisms behind hypertension. It also examines the potential of marine shellfish-derived peptides in managing hypertension. This is especially true for peptides with angiotensin-converting enzyme (ACE) inhibitory activity. ACE inhibitors play a crucial role in regulating blood pressure. They prevent angiotensin I from converting to angiotensin II. Angiotensin II is a peptide that causes vasoconstriction. Marine peptides from shellfish are being studied. These shellfish include oysters, mussels, and abalones. Researchers are looking at their ACE-inhibiting properties. They also study their potential to improve endothelial function. These peptides show promise as treatments for hypertension. Future research should focus on several areas. It should identify and optimize these peptides. It should also explore their preparation methods and bioactivity.