Vitiligo is a chronic skin condition characterized by depigmented patches resulting from the loss of melanocytes. Nongrafting surgical techniques offer alternative treatment options for patients with localized vitiligo. This review explores several key nongrafting approaches, including microneedling, dermabrasion, excision, and cryotherapy. Microneedling involves the use of fine needles to create microchannels in the skin, stimulating melanocyte migration and enhancing repigmentation. Dermabrasion, which removes the outer layers of skin, is effective for resurfacing depigmented areas and promoting pigment restoration when combined with medical therapies. Excision entails the surgical removal of vitiligo-affected skin, often followed by grafting or adjunctive treatments to facilitate pigment integration. Cryotherapy, utilizing liquid nitrogen, induces controlled freezing of lesions to destroy abnormal cells and encourage repigmentation through inflammatory responses. Each technique has distinct mechanisms, procedural protocols, and outcomes, making patient selection and personalized treatment planning crucial. This review also discusses the benefits, risks, and success rates associated with these techniques and highlights future directions for research and technological advancements. Nongrafting approaches remain valuable for managing localized vitiligo and offer various options for achieving cosmetic improvement in affected individuals.

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Nongrafting Methods (Dermabrasion, Excision, Therapeutic Wounding, and Cryotherapy)

  • Vignesh Narayan R,
  • Shyamanta Barua,
  • Rashmi Sarkar

摘要

Vitiligo is a chronic skin condition characterized by depigmented patches resulting from the loss of melanocytes. Nongrafting surgical techniques offer alternative treatment options for patients with localized vitiligo. This review explores several key nongrafting approaches, including microneedling, dermabrasion, excision, and cryotherapy. Microneedling involves the use of fine needles to create microchannels in the skin, stimulating melanocyte migration and enhancing repigmentation. Dermabrasion, which removes the outer layers of skin, is effective for resurfacing depigmented areas and promoting pigment restoration when combined with medical therapies. Excision entails the surgical removal of vitiligo-affected skin, often followed by grafting or adjunctive treatments to facilitate pigment integration. Cryotherapy, utilizing liquid nitrogen, induces controlled freezing of lesions to destroy abnormal cells and encourage repigmentation through inflammatory responses. Each technique has distinct mechanisms, procedural protocols, and outcomes, making patient selection and personalized treatment planning crucial. This review also discusses the benefits, risks, and success rates associated with these techniques and highlights future directions for research and technological advancements. Nongrafting approaches remain valuable for managing localized vitiligo and offer various options for achieving cosmetic improvement in affected individuals.