Viruses have always been a major threat to the economy and global health due to their ability to mutate, resistance to therapies, and ability to spread rapidly. Several viruses have caused epidemics/pandemics among humans, resulting in millions of deaths. On the other hand, other viruses circulate continuously in the human population, reducing the quality of life and weighing down the health and economic systems of countries through hundreds of thousands of hospitalizations. Currently, there are only a few preferred and proven antiviral drugs at all, which, unfortunately, are only effective against a limited range of viruses. Natural products research can be an effective strategy for the development of new potent antiviral drugs. Plant pathogenic viruses also present a challenge. They can cause epiphytotics and significant production losses, putting food resources in uncertainty. Antiviral substances in the agricultural sector are completely absent. The search for new antiviral substances from plant metabolites with improved efficacy and reduced side effects is of utmost importance due to the increasing species and strain biodiversity and expanded worldwide distribution. Many natural products have been identified as potential drugs in the recent past or used as models for the development of new synthetic drugs. However, less than 15% of natural sources have been studied so far.