Biopharmaceuticals have gained considerable interest since the introduction of the first recombinant therapeutic, human insulin, in 1982, which led to the development of a new branch of pharmaceutical manufacturing and therapy. The market for biopharmaceuticals has been steadily growing, as represented by the approval of >450 biopharmaceuticals in the EU and the US. The conventional bioreactors and fermentation capacities can be bottlenecks for the efficient production of biopharmaceuticals. Therefore, plants can be utilized as a viable alternative in the production of biopharmaceuticals, thereby offering a variety of options for transgene targeting and modification. This chapter will focus on the potential of plants as biological factories. The key focus will be placed on recent advancements in plant-based expression systems and the utilization of cutting-edge technologies that streamline the production of different biopharmaceuticals.