Often psychiatric comorbidity has been observed in dermatologic patients. Apart from regular dermatologic therapeutics employed in treating them; certain psychiatric drugs along with other non-pharmacological measures, if combined in managing these patients, would certainly yield superior results. This comprehensive chapter throws light on various psychiatric drugs along with other adjuvant treatment modalities that could serve as a ready reckoner to skin specialists while encountering patients, who apart from having cutaneous problems also manifest with an associated psychological component that may need scrupulous evaluation in order to obtain a proper solution.