Constructed Wetlands (CW) are being utilized globally for the past five decades. They represent an eco-friendly approach in eliminating pollutants from wastewater and can be employed in treating sewage from various sources, including sewage from municipal and industries. In recent times, the field of microbiology has experienced substantial growth, witnessing numerous innovations. Although treating wastewater with chemicals is a straightforward method, it comes at a higher cost adversely affecting the environment, leading to ecological imbalance. Adopting an environmentally friendly approach to wastewater treatment, characterized by lower costs, reduced spatial requirements, and quicker processing times, would benefit both the environment and humanity. This manuscript is dedicated to exploring the development of newly cultured bacteria for wastewater treatment, elucidating its mechanisms, and highlighting its environmental advantages. This innovative approach has successfully raised water quality standards and enhanced treatment efficiency, particularly in eliminating microorganisms such as bacteria, viruses, and fungi using other cultured microorganisms.