Scholarlink

Antioxidants had a significant attraction among biomedical researchers because of their unique property of neutralizing power with reactive oxygen species and their ability to mitigate oxidative stress. It plays a crucial role in the pathogenesis of numerous chronic diseases. Antioxidants are molecules that can be produced endogenously or exogenously by various supplementary diets by keeping safe the bimolecular such as lipids, DNA, and proteins from cellular damage, and they play a very crucial role in the development and prevention of various chronic diseases including cardiovascular, chronic kidney diseases, neurodegenerative disease, cancer, and inflammatory conditions. In the case of heart-related diseases, antioxidants and oxidative stress affect endothelial dysfunction and myocardial injury. Vitamins C, Vitamin E, and other antioxidants like polyphenols help reduce lipid peroxidation and improve vascular function. Research findings revealed that antioxidants enhance insulin sensitivity and help in reducing glucose-induced oxidative damage. Antioxidants like coenzyme Q10 and curcumin were found to have neuroprotective properties that affect the cross blood–brain barrier help in preventing neuroinflammation and preserve cognitive function. Similarly in cancer, the ROS contributes to carcinogenesis by stimulating DNA mutations, and the restricted use of antioxidants helps in preventing tumor production and multiplication through genomic stability and modulates signaling pathways. Antioxidants derived from fruits, plants, and vegetables possess strong anti-inflammatory effects and are found to have potential in treating autoimmune disorders and bone-related rheumatoid arthritis. Despite the promising preclinical and clinical findings, the healing application of the antioxidants remains very complex and sometimes very controversial due to the bioavailability, dosage level, interaction with medications, and the redox state of the target influence efficacy sometimes may lead to adverse effects. In this chapter, the potential applications of various antioxidants in the prevention and treatment of various chronic diseases, therapies with optimized delivery systems, elucidating precise mechanisms of action, and the ability of antioxidants to combat oxidative stress are discussed in detail.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Antioxidant Agents and Their Potential Applications in Treating Various Chronic Diseases

  • 章节

  • 发表日期：

    2026年

查看全文
  • H. Sowmya Lakshmi,
  • S. Subhashini,
  • D. Rajkumar,
  • R. Ramesh

摘要

Antioxidants had a significant attraction among biomedical researchers because of their unique property of neutralizing power with reactive oxygen species and their ability to mitigate oxidative stress. It plays a crucial role in the pathogenesis of numerous chronic diseases. Antioxidants are molecules that can be produced endogenously or exogenously by various supplementary diets by keeping safe the bimolecular such as lipids, DNA, and proteins from cellular damage, and they play a very crucial role in the development and prevention of various chronic diseases including cardiovascular, chronic kidney diseases, neurodegenerative disease, cancer, and inflammatory conditions. In the case of heart-related diseases, antioxidants and oxidative stress affect endothelial dysfunction and myocardial injury. Vitamins C, Vitamin E, and other antioxidants like polyphenols help reduce lipid peroxidation and improve vascular function. Research findings revealed that antioxidants enhance insulin sensitivity and help in reducing glucose-induced oxidative damage. Antioxidants like coenzyme Q10 and curcumin were found to have neuroprotective properties that affect the cross blood–brain barrier help in preventing neuroinflammation and preserve cognitive function. Similarly in cancer, the ROS contributes to carcinogenesis by stimulating DNA mutations, and the restricted use of antioxidants helps in preventing tumor production and multiplication through genomic stability and modulates signaling pathways. Antioxidants derived from fruits, plants, and vegetables possess strong anti-inflammatory effects and are found to have potential in treating autoimmune disorders and bone-related rheumatoid arthritis. Despite the promising preclinical and clinical findings, the healing application of the antioxidants remains very complex and sometimes very controversial due to the bioavailability, dosage level, interaction with medications, and the redox state of the target influence efficacy sometimes may lead to adverse effects. In this chapter, the potential applications of various antioxidants in the prevention and treatment of various chronic diseases, therapies with optimized delivery systems, elucidating precise mechanisms of action, and the ability of antioxidants to combat oxidative stress are discussed in detail.