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Metabolic syndrome (MetS) comprises a group of interconnected conditions such as obesity, insulin resistance, dyslipidemia and hypertension that substantially raise the chances of developing type 2 diabetes and cardiovascular diseases. The increasing incidence of MetS globally needs immediate attention to efficient and safer therapeutic approaches. Plant extracts serve as a promising alternative for anti-inflammatory, antioxidant properties, insulin-sensitization and other therapeutics. The clinical use of these extracts remains challenging due to their instability and poor bioavailability. Nanotechnology can be used to overcome these problems by using an advanced delivery system. Nanoformulations from plant extracts serve as effective tools for MetS management. Plant extracts have been utilized to develop various nanomedicine delivery systems, including nanoemulsions, solid lipid nanocarriers, liposomes, micelles and green-synthesized metal nanoparticles. These nanoformulations make plant-based extract more soluble and stable and offer targeted delivery as well as controlled release over time. Several studies confirm nanoformulations from curcumin, berberine, resveratrol, quercetin and other plant extracts lower oxidative damage, inflammatory responses, insulin resistance and control lipid profiles. The curcumin, resveratrol, quercetin and berberine-based nanoparticles have stronger anti-inflammatory, antioxidative, enhanced lipid and glucose regulatory effects. Plant-based nanomedicine showed their ability to control MetS-related pathways through AMPK, NF-κB and PPAR-γ systems. Further studies are required in this area to validate the safety, long-term effects and clinical effectiveness. Phytonanomedicine has the power to revolutionize the treatment of MetS while providing better therapeutic effects than conventional medicine. Plant-based nanosystems operate as a link between traditional plants and contemporary pharmaceutical delivery systems and therefore create opportunities for management and treatments of metabolic disorders.

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Phytochemical-Based Nanomedicine in the Treatment and Management of Metabolic Syndrome

  • 章节

  • 发表日期：

    2026年

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  • Vijay Kumar,
  • Padma Sharma,
  • Abhinav Sharma,
  • Nisha Kharka,
  • Kiran Toppo,
  • Komal Kumar Ingle,
  • Sachitra Kumar Ratha,
  • Vipin Rai

摘要

Metabolic syndrome (MetS) comprises a group of interconnected conditions such as obesity, insulin resistance, dyslipidemia and hypertension that substantially raise the chances of developing type 2 diabetes and cardiovascular diseases. The increasing incidence of MetS globally needs immediate attention to efficient and safer therapeutic approaches. Plant extracts serve as a promising alternative for anti-inflammatory, antioxidant properties, insulin-sensitization and other therapeutics. The clinical use of these extracts remains challenging due to their instability and poor bioavailability. Nanotechnology can be used to overcome these problems by using an advanced delivery system. Nanoformulations from plant extracts serve as effective tools for MetS management. Plant extracts have been utilized to develop various nanomedicine delivery systems, including nanoemulsions, solid lipid nanocarriers, liposomes, micelles and green-synthesized metal nanoparticles. These nanoformulations make plant-based extract more soluble and stable and offer targeted delivery as well as controlled release over time. Several studies confirm nanoformulations from curcumin, berberine, resveratrol, quercetin and other plant extracts lower oxidative damage, inflammatory responses, insulin resistance and control lipid profiles. The curcumin, resveratrol, quercetin and berberine-based nanoparticles have stronger anti-inflammatory, antioxidative, enhanced lipid and glucose regulatory effects. Plant-based nanomedicine showed their ability to control MetS-related pathways through AMPK, NF-κB and PPAR-γ systems. Further studies are required in this area to validate the safety, long-term effects and clinical effectiveness. Phytonanomedicine has the power to revolutionize the treatment of MetS while providing better therapeutic effects than conventional medicine. Plant-based nanosystems operate as a link between traditional plants and contemporary pharmaceutical delivery systems and therefore create opportunities for management and treatments of metabolic disorders.