The process of biohydrogen production from organic-rich wastewater demonstrates great potential because it generates energy while handling wastewater effectively. Organic waste transforms into hydrogen through the biological process which involves dark fermentation and photo-fermentation operations specifically. The production of biohydrogen benefits from the substrate availability present in wastewater streams that come from processing foods and paper manufacturing and agricultural operations. The wastewater treatment processes simultaneously decrease pollution while following world standards for sustainable power generation. Large-scale industrial deployment of biohydrogen remains limited by three main obstacles which consist of minimal hydrogen output rates together with operational process requirements and commercialisation financial issues. Biohydrogen has become a practical choice for industrial energy requirements because recent research in microbial engineering and process control and improved reactor designs increased yields. The combination of biohydrogen production methods with existing industrial operations through hybrid systems which unite anaerobic digestion with biohydrogen production leads to improved total efficiency of waste-to-energy systems. Judicious partnerships together with government guidelines and financial programmes need to be coupled with expanded technological capacity to commercialise industry-level hydrogen systems. Therefore, the present chapter compiles the complete knowledge about biohydrogen production from organic-rich wastewater and explains microbial and process mechanisms and suitable wastewater types, industrial integration practices and commercialisation elements. Additionally, it outlines the multiple hurdles along with open possibilities and future potential of biohydrogen technology that demonstrates sustainable energy capabilities.