Helencha or harkuch with the scientific name Enhydra fluctuans Lour is a type of herbal plant that belongs to the tropical group and is part of the Asteraceae family. This plant, which is partly submerged in water, has an importance both in medicine and as food. This plant grows best in the marsh nearby, and the vegetable is very nutritious, containing lots of nutrients, minerals, and antioxidants, which are essential for the human body. Conventional medicine has employed plant parts, especially the leaves and stems, for a broad range of illnesses, including liver problems, skin diseases, and digestive system complications. Vitamin C, vitamin A, and iron from the plant boost the body’s immunity, eyesight, and get rid of anemia problems. Furthermore, it has anti-inflammatory, antimicrobial, anti-depressant, antidiarrheal activity, and liver protective qualities attributable to the bioactive constituents of Enhydra fluctuans such as flavonoids, alkaloids, carotene, saponins, cholesterol, glucoside, enhydrin, and tannins. Based on the above health benefits of Enhydra fluctuans, it is significant to continue studying the implemented in nutrition and medicine. This chapter aims to highlight the significance of Enhydra fluctuans, known for its strong medicinal properties, and to review the research conducted on this plant to date.