The growing global population poses challenges to conventional agricultural practices, with food scarcity and famine imminent or looming on the horizon. The drive for enhanced agricultural outputs and sustainability is captured in Sustainable Development Goals (SDGs) 2. It encompasses the use of innovative and smart options for sustainable agriculture and increased food production to curb famine and hunger. The use of nanopolymer-based agro nano-chemicals is perceived to hold valuable and sustainable solutions to agricultural challenges faced in conventional systems. These nanopolymers enable precise, controlled, and eco-friendly applications of fertilisers, pesticides, and other agricultural inputs, paving the way for advanced agricultural technologies and sustainable farming practices. In this chapter, we discuss the synthesis methods commonly used to fabricate nanopolymers, their inherent properties, and areas of application in agricultural systems. Salient issues related to environmental and safety considerations and strategies for mitigating the perceived environmental impact of nanopolymer utilization are highlighted. The contribution harped regulatory and ethical considerations and future perspectives for large-scale advanced agricultural and sustainable farming practices.