American Joint Committee on Cancer (AJCC) staging includes adnexal and intraocular tumors and is an easy guide used by oncologists and respective pathologists worldwide for staging and classifying cancers. The 8th edition includes a prognostic staging system with TNM staging system. Current edition stress upon clinical, pathological, molecular pathologic studies including markers. For retinoblastoma, 8th edition incorporates hereditary ‘H’ subset which is unique out of all cancers of the human body.