The purpose of this chapter is to explore the potential for fostering a decolonizing praxis in social work with children and families. The chapter’s reflections are primarily informed by the experiences of frontline social workers engaged in implementing child protection programs targeting the Mapuche community, the largest indigenous population in Chile. Despite operating within the constraints of State-mandated guidelines, these professionals have developed intervention methodologies that reclaim and apply alternative knowledge systems—specifically, Mapuche knowledge. The findings reveal how decolonial approaches can be practically implemented, elucidating the complexities involved in such social work interventions and highlighting key lessons learned. This analysis bridges theoretical and epistemological discussions with practical social work applications, underscoring the importance of maintaining political and ethical vigilance in professional practice. The chapter advocates for interventions that foster critical consciousness, support decolonizing methodologies, and elevate the epistemologies of marginalized and excluded groups. Overall, the chapter emphasizes that sustaining a decolonizing praxis requires a commitment to promoting methodologies that challenge dominant frameworks and integrate the voices of those historically marginalized. This approach not only enriches social work practice but also aligns it with principles of justice and equity.