Canadian Nuclear Laboratories (CNL) is committed to providing safe decommissioning and operational practices for nuclear and conventional hazards. An initiative is underway to design specialized engineered waste handling and transfer equipment (referred to as the “Transfer Station”) for the staging and loading of casks in a facility. The Transfer Station is designed to operate remotely to retrieve waste packages from the transfer flasks, characterize, and transfer waste packages into shipping casks for transportation to an off-site storage location. To prevent the spread of contamination and minimize worker exposure to radiation, the Transfer Station is engineered with safety features such as shielding structures, remote operation supported by a Human Machine Interface (HMI), interlocks mechanism, a High-Efficiency Particulate Air (HEPA) filter, and negative pressure. A control room with cameras is designed to enable remote handling and monitoring of the waste packages during operation. As part of the safety analysis, a hazard analysis study was performed to identify hazards and the Postulated Initiating Events (PIEs) during the waste handling activities, and safety measures required to prevent and mitigate the radiological and occupational hazards. This paper discusses the design features of the Transfer Station and the radiological hazards during operation. The Transfer Station mitigates the radiological consequences to workers and the environment during operation. A brief description of the Transfer Station and the process of waste handling and transfer is provided. Examples of radiological risks are discussed to demonstrate the adequacy of the specialized engineered waste handling and transfer equipment for risk prevention/mitigation.