Amino acids play vital roles in various aspects of plant function, serving as crucial components for protein synthesis and essential metabolites that engage with diverse metabolic pathways. Additionally, these molecules function as key carriers of organic nitrogen within the plant. Given their pivotal role in nitrogen metabolism, the processes of amino acid biosynthesis, degradation, and transport are intricately regulated to meet the demands dictated by nitrogen and carbon availability. While our understanding of the feedback regulation within the branched biosynthesis pathways involving amino acids is substantial, the regulatory mechanisms at the transcriptional, post-transcriptional, and protein levels are still awaiting identification. This chapter primarily delves into the current comprehension of how enzymes and transporters are regulated at the transcript level under abiotic stress. Existing findings emphasize the impact of transcription factors and protein modifications, offering a fragmented yet insightful perspective that suggests a multitude of intricate regulatory layers governing the coordination of transport and enzyme activities. Notably, the regulation of amino acid metabolism, transport, and integration of stress signals appears to exhibit a complex interplay that, as of now, remains challenging to predict with certainty.