Prevention, intervention, and rehabilitation are very important aspects when you address an issue in an individual and community level. Prevention is addressing the issue in the early level or even before the issue happens while intervention targets the affected population in order to reduce the harm, while rehabilitation focuses on the basis of harm reduction and reintegration. For an issue like sex work these aspects should be taken in multiple levels. This chapter gives a glimpse on the various prevention, intervention and rehabilitation activities taken place across the globe till date. It also gives a critical evaluation on the same also the issues and challenges in implementing the same.