Challenges are an inevitable part of any sex worker regardless of their nationality, gender, age, and so all. In other words, we can say that they have hardships in every domain of life. This chapter exclusively deals with the challenges faced by commercial sex workers. The chapter consists of the challenges in different domains of a sex worker’s life, viz., economic challenges, social challenges, and challenges related to exit. Social challenges focus mainly on violence and discrimination, and the factors contributing to it. The chapter concludes with the need for multi-level interventions to deal with the issue.