Wireless sensor network, as a distributed wireless network system, applied in the nuclear environment, can reduce the monitoring system cable wiring workload, reduce the impact of cable aging and termination failures in the use and maintenance of devices in the nuclear environment, and contribute to the enhancement of the level of automation and informationization of the devices in the nuclear environment as well as the integration and miniaturization of the devices. However, its application is also faced with the constraints of the special complex nuclear environment, such as strong ray and neutron irradiation, radio frequency and severe electromagnetic interference. Aiming at the γ radiation in the nuclear environment, the suitable thickness and overall structure of the radiation shielding reinforcement for the wireless sensors and gateways used in nuclear power plants are obtained through the analysis of the shielding material properties, MCNP program simulation, and the design and layout of the shielding structure; and the thickness of the designed anti-irradiation shield to withstand the cumulative irradiation dose of 1000Gy with different materials is obtained through the simulation verification. This study provides a design basis for the design of irradiation-resistant shielded prototypes for wireless sensors and networks and subsequent smart meters.