A comprehensive utilization system of nuclear energy is a carbon-free and environment-friendly way. For existing nuclear power units, a comprehensive utilization system of nuclear energy introduces coupling relations among different systems. This study proposes a coordinated control system for VVER-1000 nuclear power plants to extract steam from the main steam header for industrial cogeneration. First, a dynamic model of the VVER-1000 cogeneration system is developed. Then, the control requirements are systematically analyzed. The main steam header pressure is converted into the corresponding nuclear power, and the coordinated control system is designed to adjust the power mismatch between the nuclear power and load. At last, the coordinated control system is verified by the electrical power step and thermal energy fluctuation based on the simulation platform. The results show that the power mismatch eventually stabilizes within the range of ±5%, and the main steam header pressure remains stable within ±0.5 MPa of the setpoint. This paper can provide a reference for the flexible and feasible control scheme of nuclear power plants.