This study focuses on the coordinated development of regional logistics and economy in the Yangtze River Delta, aiming to explore their coupling coordination level and influencing factors. By constructing a coupling coordination model and using multiple regression analysis, this research thoroughly analyzes the impact of factors such as logistics infrastructure construction, logistics service efficiency, technological innovation, policy support, economic development level, and industrial structure adjustment on the coordinated development of regional logistics and economy in the Yangtze River Delta. The findings reveal that both the coupling degree and coordination degree between the logistics and economic systems in the Yangtze River Delta show an upward trend, indicating an increasingly strong interdependence and interaction between the two. Particularly, technological innovation and policy support play key roles in promoting the coordinated development of logistics and economy. Based on the analysis, this paper proposes a series of policy recommendations, including increasing investment in logistics infrastructure, encouraging technological innovation, and optimizing the policy environment, aiming to further promote the high-quality coordinated development of the regional logistics and economy in the Yangtze River Delta.