131I is a significant radioisotope with both diagnostic and therapeutic applications. It is extensively used in the diagnosis of thyroid diseases and tumors, as well as in the treatment of hyperthyroidism and thyroid cancer. This study utilizes the High Temperature Gas-Cooled Reactor Pebble-Bed Module (HTR-PM) to irradiate a target in the neutron source channels for 131I. The changes of the key isotopes with irradiation time, the yield of 131I, and the content of impurities in the target at the end of the irradiation for the production with the use of natural and enriched targets were calculated, and the isotope production capacity of the high temperature gas-cooled reactors (HTGRS) was preliminarily evaluated. The results showed that the optimal irradiation time for both natural and concentrated targets is 53 days. For concentrated targets, the relevant parameters of the product meet the drug quality requirements 4.6 hours after exiting from the channel. It shows that the production of 131I using HTR-PM is feasible in terms of yield, which helps promote the development of isotope production technology in HTGRs.